FDA Commissioner Marty Makary is stepping down to become the new acting leader

Food and Drug Administration (FDA) Commissioner Marty Makary resigned on Tuesday, a White House official told Fox News Digital.

The official said Makary’s resignation was related to “FDA process” and not a specific issue, and said there was “no bad blood” between President Donald Trump and the outgoing commissioner. Secretary of Health and Human Services Robert F. Kennedy Jr. pushed for Makary to step down, according to a White House official.

Kyle Diamantis, the FDA’s deputy commissioner for food, will serve as acting commissioner, Fox News Digital said.

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Makary’s resignation follows mounting pressure from pro-life advocates and administration critics who were frustrated by his handling of high-level FDA decisions and who say he has made MAHA programs slow, according to media reports in recent weeks.

The Wall Street Journal on Friday reported that the president has reportedly signed off on the plan to fire Makary, citing three well-known sources who cited Makary’s handling of abortion and drug policy.

“I’ve been reading about it, but I don’t know anything about it,” Trump said the same day after being asked by reporters if Makary would be fired.

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The resignation comes one day before Makary is scheduled to testify before the Senate Appropriations Committee on Wednesday.

Although Makary’s resignation may be due to a specific issue, according to a White House official, his tenure at the FDA has put him at the center of the fight against the abortion drug mifepristone – known as the “abortion pill” – vaccine policy and drug approval, which frustrates health activists and MAHA-aligned critics and has gradually pushed health critics forward.

When Trump was elected, pro-life groups and voters were banking on retroactive Biden-era laws that allowed mifepristone to be prescribed online and sent by mail. But the FDA left those rules intact and last year, under Makary’s leadership, approved a new version of the generic pill.

“President Trump and Secretary of Health and Human Services Kennedy must end this now, remove Commissioner Makary, stop the abortion-by-mail program, and take these killer drugs off the market,” Live Action president Lila Rose wrote to Fox News Digital before Makary’s resignation.

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“President Trump and Secretary of Health and Human Services Kennedy must end this now, remove Commissioner Makary, stop the abortion-by-mail program, and take these killer drugs off the market,” Live Action president Lila Rose wrote to Fox News Digital before Makary’s resignation. (Photo by Andrew Harnik/Getty Images)

“What a mess Makary was,” a Trump administration official told Fox News Digital in early May, saying the commissioners’ comments and actions showed that “every health care advocate is self-centered.”

“The arrogance is astounding,” added the FDA commissioner.

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Makary’s exit follows a string of top guests this year, including former Homeland Security Secretary Kristi Noem and former Attorney General Pam Bondi. (Andrew Harnik/Getty Images)

Susan B. Anthony Pro-Life America President Marjorie Dannenfelser told the The Wall Street Journal in early May that “Trump is the problem,” when it comes to abortion issues that have fallen to the GOP in recent years.

And if candidates want his party’s $160 million in the midterms and the 2028 presidential election, he said they must commit to “supporting national health.”

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Makary’s exit follows a string of top guests this year, including former Homeland Security Secretary Kristi Noem and former Attorney General Pam Bondi.

Fox News Digital’s Paul Steinhauser contributed to this report.